Sabrina Leslie presents at PepTalk 2026
Sabrina Leslie presented at PepTalk (January 19–22, 2026) on the application of CLiC technology for single-particle, high-resolution characterization of mRNA–lipid nanoparticles (mRNA-LNPs). Her talk highlighted how CLiC enables deep insight into payload content and molecular organization at the individual particle level capabilities that are increasingly critical for the development and optimization of nucleic acid therapeutics. […]
When it comes to mRNA, seeing is believing
We are moving into a new era of genomic medicines that will target cancer, viruses and disease by editing our DNA and RNA. But the path to developing these drugs is not yet clear because of the incredibly small-scale drug developers are working with — our cells — and the complexity of the activities within […]
Next steps in driving forward the field of nanomedicine: A catch-up with the Leslie lab
The lab of Dr. Sabrina Leslie (MSL, Physics and Astronomy; SBME affiliate member) brings together researchers and approaches from physics and biology to drive forward the field of nanomedicine. Their work involves the use of their high-resolution Convex Lens-induced Confinement (CLiC) imaging technology to look closely at lipid nanoparticles (LNPs), which can act as delivery […]
Single Molecule Imaging in the Leslie Lab: Video Spotlight
Biofilm MEDIA, with support from Nikon Canada Inc., recently met with the Michael Smith Laboratories’ Leslie Lab to feature their work in single molecule imaging. “We’re also pushing the limit with optics to look at untethered single macromolecules. And with partners like Nikon, we are excited to be rapidly advancing the field of genomic medicines […]
Drs. Leonard Foster and Sabrina Leslie awarded CFI Innovation Fund grants
Congratulations to Dr. Leonard Foster and Dr. Sabrina Leslie on being awarded grants through the Canada Foundation for Innovation (CFI) Innovation Fund! This funding will allow Foster and Leslie to acquire new equipment that will help to advance their research projects. Their research projects will contribute to the fundamental science understanding of viral infection at […]
Yao Zhang – Mary Adele Normal Postgraduate Award in Medical research
Congratulations to graduate student Yao Zhang, co-supervised by Drs. Sabrina Leslie and Pieter Cullis, for being awarded the Mary Adele Norman Postgraduate Award in Medical Research from the Faculty of Medicine.
Vancouver Nanomedicine Day 2023
In this presentation from Vancouver Nanomedicine Day 2023, Dr. Sabrina Leslie discusses her work on single-particle & single-cell imaging to quantitate biophysical properties of mRNA lipid nanoparticles & engineer improved vaccines & therapies. https://youtu.be/N1F82BwU2cU
NMIN Round 4 Grant
NMIN’s Round 4 grant is intended to support the continuation of completed NMIN Strategic Initiative research projects which demonstrate high potential for commercialization and clinical translation. The Leslie Lab is happy to announce that we have been awarded $200,000 over two years to continue the research we started in 2020 thanks to support from NMIN. […]
Unlocking the secrets of single cells to improve therapeutics
With recent advancements in single-cell analysis and imaging, the MSL’s Leslie Lab is emerging as a leader in this rapidly growing field of research. Working at the intersection of physics and biology, the lab is focused on developing a better understanding of single-cell and molecule interactions that could improve medical therapies. In the fall of […]
Frontiers in Biophysics Conference
The annual Frontiers in Biophysics (FiB) conference was held here at UBC this year, with Sabrina serving as a faculty mentor to this student-run conference. This year attendance was at a record high, and it was the first time FiB had an international Keynote speaker as well as a career panel. Participants from diverse backgrounds came […]