NMIN's Grand Challenges Grant
This grant is intended to fund ambitious research programs that offer the potential for large benefits to society. Multidisciplinary teams will conduct research that will keep Canada in the vanguard of nanomedicine technology development.
The Leslie Lab is excited to announce that we are joining a talented team of scientists who have been awarded $1,500,000 collectively to collaborate on research which is focused on the development, optimization, and evaluation of novel nanoparticle formulations for extra-hepatic targeted gene therapy. This will be led Drs. Blakney, Cullis, Leslie, Foster, Harder, Ross, and Bertrand.
More information can be found here
UBC Support for Teams to Advance Interdisciplinary Research Grant (July 2022)
Interdisciplinary collaborations are necessary to tackle challenging problems in science and UBC’s Support for Teams to Advance Interdisciplinary Research (STAIR) grants serve as a starting point for impactful research that can later be taken further by external funding opportunities.
The Leslie Lab is pleased to announce that we will be conducting collaborative research with Ed Grant and his team. Our aim is to combine Convex Lens-induced Confinement (CLiC) microscopy pioneered by Sabrina with interferometric scattering microscopy (iSCAT) techniques developed by Ed to create a novel analytical tool for molecular biology.
First PacifiCan Microscope Received (June 2022)
We received our new Nikon AX R microscope and our team is very excited for the research we’ll be able to accomplish with this! We are honored to be the second laboratory in western Canada to house the AX R. Thank you to PacifiCan for making this possible!
See link for more information: AX / AX R
Telluride Science Research Center Workshop (June 2022)
Sabrina was invited to give a talk at a workshop in beautiful Telluride, Colorado and found time to do some hiking! Sabrina visits Telluride every two years and is grateful that these workshops have resumed following the COVID-19 pandemic.
Interdisciplinary theorists and experimentalists from a broad range of fields were brought together to discuss topics in biophysics, kinetics, imaging, and spectroscopy. While in Telluride, Sabrina had the opportunity to connect with Dr. Brian Munsky and others. We have been working closely with Dr. Munsky and his research group for many years and this has led to a recent publication in Nucleic Acids Research (Shaheen et al. 2022).
Frontiers in Biophysics 2022 (June 2022)
The Leslie Lab attended the Frontiers in Biophysics 2022 conference in downtown Vancouver!
We had a great time sharing our posters, watching presentations, and engaging in conversation with other biophysicists. The conference was focused on quantitative biology and biophysics and we are looking forward to next year’s event!
More information can be found here
Liposome Research Days 2022 (June 2022)
Members of the Leslie Lab attended the 17th Liposome Research Days right here in Vancouver at the University of British Columbia!
One of our postdocs, Albert Kamanzi, gave a talk on lipid nanoparticle fusion dynamics. Other members of our lab got to watch presentations, build meaningful connections, and socialize with other researchers interested in similar topics.
Thank you to the organizers of the event! More information can be found here
UBC School of Biomedical Engineering Annual Symposium (June 2022)
The Leslie Lab was represented at the UBC School of Biomedical Engineering (SBME) Symposium by several members of our team.
It was a wonderful opportunity to share our findings with the broader UBC community and we look forward to attending again next year!
More information can be found here
UBC Killam Accelerator Research Fellowship (June 2022)
Sabrina receives UBC’s 2021 faculty research award with the UBC Killam Accelerator Research Fellowship (KARF), supporting early-career researchers ready to launch the next stage of their careers. Find the official announcement here.
Faculty Research Awards, such as the KARF, recognize the research excellence and scholarly achievements of faculty from across all disciplines, ranging from medicine and applied and natural sciences to arts, social sciences and humanities. Recipients span from early career researchers to senior members of faculty.
Winners were selected by UBC’s Faculty Research Award Committee.
The Office of the VP, Research and Innovation will be hosting a reception on June 3, 2022 to acknowledge the achievements of researchers.
Congratulations to all recipients!
Biophysical Society of Canada Annual Meeting (May 2022)
Two of our PhD students, Cindy Shaheen and Frank Stabile, attended the Biophysical Society of Canada’s annual meeting in Ottawa, Ontario. Frank presented a poster on CRISPR kinetics and Cindy presented a poster and a student talk on DNA structural dynamics.
Congratulations to Cindy for winning the BSC travel award!
More information can be found here
Keystone Symposia (May 2022)
This year’s symposium gathered top researchers working in small RNAs to discuss their biology and to foster the invention of powerful clinical tools by employing RNAs in novel ways.
Sabrina was invited to speak in Santa Fe, New Mexico where Convex Lens-induced Confinement (CLiC) microscopy was recognized as an emerging technology important to RNA-based therapeutics.
More information can be found here
NMIN Undergraduate Studentship Awardees 2022
Faith Liu
University of British Columbia
Supervisor: Dr. Sabrina Leslie
Project Summary: This project will study changes in the biophysical properties of mRNA-delivery lipid nanoparticles (LNPs) as a function of buffer pH and ionic strength, toward better understanding the mechanisms of action of these important classes of LNP-RNA therapeutics and vaccines.
Career Aspirations: My career goal is to work in biological and medical science, toward helping society through new research and discoveries.
Amanda Yao
University of British Columbia
Supervisor: Dr. Sabrina Leslie
Project Summary: This project will advance a fluorophore-quencher probe to use as a diagnostic tool to quantitate specific, single-stranded DNA of interest with single-molecule sensitivity.
Career Aspirations: I hope to continue my studies in PharmD and pursue a career in pharmaceutical sciences, working on drug development with a focus on researching new drug delivery techniques.
Pacific Economic Development Canada (PacifiCan) Award
Formerly known as Western Economic Diversification Canada (WD), the PacifiCan Award is administered in British Columbia to promote a strong, competitive economy by supporting business, innovation, and economic development.
Our lab has received 1.75 million dollars in funding for 3 new microscope platforms and we congratulate Dr. Leonard Foster for also receiving 1.75 million dollars in funding for mass spectrometers here at the Michael Smith Laboratories.
More information can be found here
Biophysics Day 2022 (Feb 2022)
Earlier this week we got together with the other Biophysics labs at UBC for the first-ever Biophysics Day event. Each group introduced their research with a series of fantastic graduate student presentations and it was an amazing chance to meet folks within the department.
Huge thanks to the Michal, Plotkin, and Rottler labs for joining us and to the student committee for organizing the event. Looking forward to the next one!
New Publication: Shaheen et al.
Non-equilibrium structural dynamics of supercoiled DNA plasmids exhibits asymmetrical relaxation
We are very pleased to announce that Cindy Shaheen, a senior PhD student in our lab, recently published an article in Nucleic Acids Research. This work uses convex lens-induced confinement (CLiC) to study the non-equilibrium dynamics of highly structured plasmid DNA from a single-molecule perspective. You can read more about her exciting work here:
We would also like to give thanks to our incredible collaborators David Levens and Fed Kouzine at the NIH, Craig Benham at UC Davis, and Brian Munsky at Colorado State University for their invaluable support along the way.
Congratulations Cindy for this huge achievement! The publication can be found here
NMIN Strategic Initiative Program (Jan 2021)
NMIN’s Strategic Initiatives (SI) program aims to support quick responses to time sensitive research problems, commercialization of IP, mobilization of knowledge garnered from NMIN-funded research, and growth of the Canadian nanomedicines field through support of new and existing companies.
The image below is a NMIN PharmaCore resource. The original image and more information can be found here.
The Big Move - McGill to UBC (Jan 2021)
Here’s to new beginnings! The Leslie Lab will be relocating from McGill to the University of British Columbia.
Thank you to our colleagues at McGill for everything you have done for us, it’s never easy to say goodbye. We are excited for what’s to come and we will be resuming research operations shortly.
