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Research overview

The Leslie Lab is working at the interface of physics and biology with a particular interest in quantifying the dynamics of individual molecules. Dr. Leslie’s research provides insights into the biophysical properties of molecules and cells, including therapeutics with the ultimate goal of propelling quantitative health sciences. Her team is developing single-molecule and single-cell imaging and analysis tools, as well as mathematical models of molecular interactions, to help guide the rational design of new therapeutic molecules and delivery vehicles. These discoveries will elucidate the process of how molecules search for and bind to a target and perform their therapeutic function in a complex living environment, with a particular focus on nucleic acid interactions and advancing genetic medicines. Current projects include: understanding the biophysics of nucleic acid hybridization, understanding the mechanisms of antisense oligonucleotides, protein-protein interactions, and single- molecule activity in whole cells.

Dr. Sabrina Leslie receives CFI funding to advance therapeutics research and development

Michael Smith Laboratory researcher and UBC Physics & Astronomy Associate Professor Dr. Sabrina Leslie has been awarded funding to set up a single-molecule and single-cell microscopy platform for therapeutics research and development. The project is funded through the Canada Foundation for Innovation (CFI) John R. Evans Leaders Fund (JELF) ($462K), with matching funds from the British Columbia Knowledge Development Fund (BCKDF) and additional support from other funding partners. This laboratory is among the 37 selected to receive a total of $5.7M CFI JELF investment here at UBC. More here